Thermo Scientific SickleScreen products use a modified Nalbandian procedure that provides fast and accurate results for screening and detecting hereditary sickle cell disease and sickle cell trait. When sickle cell patients are in crisis, their Hb S becomes sickle or cresent shaped and can no longer carry oxygen
The abnormal cells often break apart and can cause damage to the spleen, kidneys, bone, eyes, lungs and central nervous system
The procedure is based on the differential solubility of Hemoglobin S (Hb S) and Hemoglobin A (Hb A) in concentrated phosphate solution
